Figure 1 from In Vitro and in Vivo Adenovirus Biology Diagrams
BlogFigure 1 from In Vitro and in Vivo Adenovirus Biology Diagrams Here, we provide an overview of the important roles of p53, p21, and p16 in the cell-intrinsic checkpoint, signaling, and repair responses to prevent genome instability. The significance of these tumor suppressors is also discussed in the context of cancer and DNA-damaging therapies designed to specifically target tumor cells. While the molecular mechanism of senescence involves p16 and p53 tumor suppressor genes and telomere shortening, this review is focused on the mechanism of p16 control. The p16 mediated senescence acts through the retinoblastoma (Rb) pathway inhibiting the action of the cyclin dependant kinases leading to G1 cell cycle arrest.
Another consequence of the E7-mediated pRb degradation is the overexpression of p16, a potent tumor suppressor. The detection of p16 overexpression has been adopted as a molecular hallmark of HPV-associated OPSCCs, with studies demonstrating its positive effect on patient survival.
p53 pathway constrain progression of ... Biology Diagrams
Here, we describe rezatapopt (PC14586), part of a series of compounds designed to reactivate the p53 Y220C mutant. These compounds restore p53 tumor suppressor function by correcting its conformation and enabling it to bind DNA and activate downstream target genes, thus inducing anti-proliferative changes in tumor cells. Currently, p16 Ink4a is considered a tumor suppressor protein because of its physiological role and downregulated expression in a large number of tumors. The present study aimed to explore the significance of tumor suppressor proteins and HPV16 E6 and E7 oncoproteins in the assessment of survival in patients with oropharyngeal squamous cell carcinoma (OPSCC), LSCC, and HPSCC associated with high-risk (HR-) and low-risk (LR-) HPV infections.
While the identity of P16ฮณ or P12 as a tumor suppressor remains to be established, it is safe to state that P16, P15, and P14ARF together constitute one of the primary anti-tumor defenses in human through strict regulation of both pRb and P53 pathways.
The Role of the p16 and p53 Tumor Suppressor Proteins and ... Biology Diagrams
Collectively, our results establish that disruptions of p16 Ink4a and the p19 ARF -p53 circuit play critical and cooperative roles in PDAC progression, with specific tumor suppressor genotypes provocatively influencing the tumor biological phenotypes and genomic profiles of the resultant tumors.
